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超声 3

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成像 2

4Pi-SMLM 1

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High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience

Lian ZHANG, Zhi-Biao WANG

《医学前沿（英文）》 2010年 第4卷 第3期   页码 294-302 doi: 10.1007/s11684-010-0092-8

摘要： High-intensity focused ultrasound (HIFU) is a technique to destroy tissue at depth within the body, selectively and without harming overlying and adjacent structures within the path of the beam because the ultrasonic intensity at the beam focus is much higher than that outside of the focus. Diagnostic ultrasound is the first imaging modality used for guiding HIFU ablation. In 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups’ reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors. HIFU is a promising technique. Most importantly, HIFU offers patients another alternative when those patients have no other treatment available.

关键词： high-intensity focused ultrasound (HIFU)     ultrasound imaging-guided HIFU (USgHIFU)     magnetic resonance imaging-guided HIFU (MRgHIFU)    

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基于超声引导的高精度机器人辅助HIFU 乳腺癌治疗系统 Article

Tianhan Tang,Takashi Azuma,Toshihide Iwahashi,Hideki Takeuchi,Etsuko Kobayashi,Ichiro Sakuma

《工程（英文）》 2018年 第4卷 第5期   页码 702-713 doi: 10.1016/j.eng.2018.07.008

摘要： 高强度聚焦超声（波）（HIFU）是一种很有前景的非介入式治疗方法。为了提高HIFU 治疗的精确度和降低治疗成本，开发了一套基于超声引导（US）的五自由度辅助HIFU 系统。搭建了一套功能齐全的样机，它可以轻松地实现三维超声图像重建、目标分割、治疗路径生成和HIFU 自动照射等功能。利用线模型实现点定位，并且在异构组织模型上对凝固区域进行评估。在超声引导下，HIFU 治疗区域的中心偏离目标治疗区域中心不到2 mm。规划治疗区域周围出现的超调值远低于在临床使用的允许值。对于乳腺癌的治疗，本系统有足够的准确性。

关键词： HIFU     乳腺癌     超声引导     医疗机器人     准确性评估    

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Ultrasound-guided prostate percutaneous intervention robot system and calibration by informative particle

《机械工程前沿（英文）》 2022年 第17卷 第1期   页码 3-3 doi: 10.1007/s11465-021-0659-x

摘要： Applying a robot system in ultrasound-guided percutaneous intervention is an effective approach for prostate cancer diagnosis and treatment. The limited space for robot manipulation restricts structure volume and motion. In this paper, an 8-degree-of-freedom robot system is proposed for ultrasound probe manipulation, needle positioning, and needle insertion. A novel parallel structure is employed in the robot system for space saving, structural rigidity, and collision avoidance. The particle swarm optimization method based on informative value is proposed for kinematic parameter identification to calibrate the parallel structure accurately. The method identifies parameters in the modified kinematic model stepwise according to parameter discernibility. Verification experiments prove that the robot system can realize motions needed in targeting. By applying the calibration method, a reasonable, reliable forward kinematic model is built, and the average errors can be limited to 0.963 and 1.846 mm for insertion point and target point, respectively.

关键词： ultrasound image guidance     prostate percutaneous intervention     parallel robot     kinematics identification     particle swarm optimization     informative value    

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Anefficient quadrature demodulator for medical ultrasound imaging

Hao ZHOU,Yin-fei ZHENG

《信息与电子工程前沿（英文）》 2015年 第16卷 第4期   页码 301-310 doi: 10.1631/FITEE.1400205

摘要： Quadrature demodulation is used in medical ultrasound imaging to derive the envelope and instantaneous phase of the received radio-frequency (RF) signal. In quadrature demodulation, RF signal is multiplied with the sine and cosine wave reference signal and then low-pass filtered to produce the base-band complex signal, which has high computational complexity. In this paper, we propose an efficient quadrature demodulation method for B-mode and color flow imaging, in which the RF signal is demodulated by a pair of finite impulse response filters without mixing with the reference signal, to reduce the computational complexity. The proposed method was evaluated with simulation and in vivo experiments. From the simulation results, the proposed quadrature demodulation method produced similar normalized residual sum of squares (NRSS) and velocity profile compared with the conventional quadrature demodulation method. In the in vivo color flow imaging experiments, the time of the demodulation process was 5.66 ms and 3.36 ms, for the conventional method and the proposed method, respectively. These results indicated that the proposed method can maintain the performance of quadrature demodulation while reducing computational complexity.

关键词： B-mode ultrasound imaging     Color flow imaging     Quadrature demodulation     Finite impulse response filter    

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高能聚焦超声热治疗恶性肿瘤的初步探索——附78例治疗临床应用报告

何申戌,熊六林,于晋生,兰江

《中国工程科学》 1999年 第1卷 第2期   页码 62-66

摘要：

目的 了解HIFU技术治疗癌瘤的临库效果和安全性。结论 HIFU技术对控制肿瘤有肯定疗效，并且安全可靠，值得推广应用；其相关医学基础研究须尽快开展。

关键词： 癌     热疗     体外聚焦     超声    

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肿瘤光学分子影像前沿技术：追求更精准和更灵敏 Review

王坤,迟崇巍,胡振华,刘沐寒,惠辉,尚文婷,彭冬,张爽,叶津佐,刘海哮,田捷

《工程（英文）》 2015年 第1卷 第3期   页码 309-323 doi: 10.15302/J-ENG-2015082

摘要：

以新发展的光学多模成像、契伦科夫荧光成像和光学影像手术导航技术为代表的光学分子影像前沿技术，开辟了肿瘤研究、临床转化和医疗实践的新前沿领域。相对于传统成像技术，新技术在活体肿瘤成像上可以提供前所未有的灵敏度和精准度。活体肿瘤细胞和分子行为与事件的可视化正在系统地促进人们对肿瘤的深度理解。这些成像技术的新进展正被快速应用于肿瘤诊疗，如对不同肿瘤之间分子异质性信息的动态和量化获取， 以及通过实时成像辅助实现更有效的治疗性干预。在分子影像的时代中，光学技术为促进高灵敏度肿瘤诊断和个体化治疗的发展带来了巨大的希望，而这些正是精准医学的终极目标之一。

关键词： 光学分子影像     多模分子成像     光学多模断层成像     契伦科夫荧光成像     光学影像手术导航    

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Time reversal method for guided wave inspection in pipes

DENG Fei, WU Bin, HE Cunfu

《机械工程前沿（英文）》 2008年 第3卷 第3期   页码 251-260 doi: 10.1007/s11465-008-0050-1

摘要： The application of the time reversal method in pipe-like structures based on finite element method (FEM) is investigated. A steel pipe model measuring 70 mm × 3.5 mm is used to analyze the reflection coefficient of the (0,2) mode with the time reversal process. Simulation results show that the time reversal array method is beneficial to the improvement of the signal-to-noise ratio of a guided wave inspection system. As the intercepting window is widened, more energy is included in re-emitted signals, which leads to a large reflection coefficient of the (0,2) mode. In parallel, a circumferential locating method based on the time reversal method is described. The time reversal process used for guided wave inspection leads to the temporal and spatial focusing. When the time reversal signals are re-emitted, the angular profile obtained at the axial location of the defect can be used to determine the circumferential location of the defect. Except for a pipe with one defect, the circumferential locating method has been verified on another pipe model with two defects. Meanwhile, the elements number of the time reversal array has been discussed for enhancing the discrimination of the defect circumferential location.

关键词： reversal process     beneficial     circumferential location     energy     number    

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Synthesis and characterization of phosphotungstic acid/activated carbon as a novel ultrasound oxidative

Liyan LIU, Yu ZHANG, Wei TAN

《化学科学与工程前沿（英文）》 2013年 第7卷 第4期   页码 422-427 doi: 10.1007/s11705-013-1353-2

摘要： Phosphotungstic acid/activated carbon (PTA/AC) catalysts with various AC sizes or PTA content have been synthesized and characterized by N physisorption, X-ray diffraction, Fourier transform infrared spectroscopy and temperature programmed desorption of ammonia. These catalysts were then evaluated in terms of the removal of dibenzothiophene (DBT) by ultrasound-assisted oxidative desulfurization process. The results showed that the DBT conversion obviously increased with the decrease of AC support size and the increase of PTA content. After supporting PTA on AC, the DBT conversion can be improved by 38.9% after ultrasound irradiation for 10 min. In addition, the stability tests of PTA/AC showed that the catalytic oxidative activity of PTA/AC was nearly kept constant after ultrasound irradiation for 20 min, which makes it a promising catalyst to use in ultrasound-assisted oxidative desulfurization process.

关键词： phosphotungstic acid     activated carbon     ultrasound-assisted oxidative desulfurization    

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Studies of ultrasound disintegration of residual sludge and its energy consumption in water treatment

SHEN Jinfeng, YIN Xuan, GU Heping, Lv Xiaoping

《化学科学与工程前沿（英文）》 2007年 第1卷 第4期   页码 395-398 doi: 10.1007/s11705-007-0072-y

摘要： To investigate the influence of ultrasound pretreatment on sludge anaerobic digestion, the ultrasound disintegration of residual sludge in water treatment of petrochemical plant was studied, and the mechanisms of ultrasound and medium were introduced. Experimental results indicate that ultrasound cavitation induces the rise of sludge temperature, which improves ultrasound disintegration on sludge. U1trasound pretreatment can advance observably the quantity of chemical oxygen demand in sludge supernatant fluid (SCOD), which increases with ultrasound intensity and sonication time. The degree of ultrasound disintegration increases with the specific energy input. When the specific energy input is l0 000 kJ/kg of total dry solids, the degree of ultrasonic sludge disintegration reaches 40%.

关键词： specific     supernatant     petrochemical     ultrasound intensity     temperature    

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图引导正则最小化的随机超梯度的交替方向方法 None

Qiang LAN, Lin-bo QIAO, Yi-jie WANG

《信息与电子工程前沿（英文）》 2018年 第19卷 第6期   页码 755-762 doi: 10.1631/FITEE.1601771

摘要： 提出并比较额外梯度交替方向的几种随机变体方法，称为带拉格朗日函数（SEGL）的随机超梯度交替方向法和带增广拉格朗日函数（SEGAL）的随机超梯度交替方向法。这些方法由两个大规模凸目标函数组成，可最小化图形引导的优化问题。机器学习中一些重要应用遵循图导引优化公式等作为线性回归、逻辑回归、Lasso结构化扩展以及结构化正则化逻辑回归的原则。通过融合逻辑回归和图形引导正则化回归，在几类数据集上进行了试验。试验结果表明所提算法优于其他竞争算法，且在实际应用中，SEGAL比SEGL性能更好。

关键词： 随机优化；图形引导最小化；超梯度法；融合逻辑回归；图导向正则化逻辑回归    

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Entity and relation extraction with rule-guided dictionary as domain knowledge

《工程管理前沿（英文）》   页码 610-622 doi: 10.1007/s42524-022-0226-0

摘要： Entity and relation extraction is an indispensable part of domain knowledge graph construction, which can serve relevant knowledge needs in a specific domain, such as providing support for product research, sales, risk control, and domain hotspot analysis. The existing entity and relation extraction methods that depend on pretrained models have shown promising performance on open datasets. However, the performance of these methods degrades when they face domain-specific datasets. Entity extraction models treat characters as basic semantic units while ignoring known character dependency in specific domains. Relation extraction is based on the hypothesis that the relations hidden in sentences are unified, thereby neglecting that relations may be diverse in different entity tuples. To address the problems above, this paper first introduced prior knowledge composed of domain dictionaries to enhance characters’ dependence. Second, domain rules were built to eliminate noise in entity relations and promote potential entity relation extraction. Finally, experiments were designed to verify the effectiveness of our proposed methods. Experimental results on two domains, including laser industry and unmanned ship, showed the superiority of our methods. The F1 value on laser industry entity, unmanned ship entity, laser industry relation, and unmanned ship relation datasets is improved by +1%, +6%, +2%, and +1%, respectively. In addition, the extraction accuracy of entity relation triplet reaches 83% and 76% on laser industry entity pair and unmanned ship entity pair datasets, respectively.

关键词： entity extraction     relation extraction     prior knowledge     domain rule    

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evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

null

《医学前沿（英文）》 2014年 第8卷 第4期   页码 471-476 doi: 10.1007/s11684-014-0365-8

摘要：

This work aims to estimate the value of diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) in detecting early-stage kidney injury in type 2 diabetic patients with normoalbuminuria (NAU) versus microalbuminuria (MAU) prospectively. A total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU group (n = 14) or MAU group (n= 16) according to 8 h overnight urinary albuminuria excretion rate (AER) results. A contemporary cohort of health check-up recipients were included as controls (n = 12). DWI and DTI scans were performed on bilateral kidney using SE single-shot EPI, and apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the renal parenchyma was determined from ADC and FA maps of the three groups. ADC and FA values were compared among the three groups. According to DWI with a b value of 400 s/mm2, the MAU and NAU groups showed significantly lowered mean ADC values compared with the healthy controls (P<0.01). The mean ADC in the MAU group [(2.22±0.07)×10–3 mm2/s] was slightly lower than that of the NAU group [(2.31±0.22)×10–3 mm2/s], but this difference was not statistically significant (P>0.05). The FA value in the MAU group was higher than that in the control group (0.45±0.07 vs. 0.39±0.03, P = 0.004) but did not differ from that in the NAU group (0.42±0.03) (P>0.05). ADC and FA values may be more sensitive than urine AER in reflecting early-stage kidney injury and, hence, may facilitate earlier detection and quantitative evaluation of kidney injury in T2DM patients. Combined evaluation of ADC and FA values may provide a better quantitative approach for identifying diabetic nephropathy at early disease stages.

关键词： type 2 diabetes mellitus     microalbuminuria     diffusion weighted imaging     diffusion tensor imaging     early-stage kidney injury    

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Using ultrasound to improve the sequential post-synthesis modification method for making mesoporous Y

Rongxin Zhang, Peinan Zhong, Hamidreza Arandiyan, Yanan Guan, Jinmin Liu, Na Wang, Yilai Jiao, Xiaolei Fan

《化学科学与工程前沿（英文）》 2020年 第14卷 第2期   页码 275-287 doi: 10.1007/s11705-019-1905-1

摘要： Mesoporous Y zeolites were prepared by the sequential chemical dealumination (using chelating agents such as ethylenediaminetetraacetic acid, H EDTA, and citric acid aqueous solutions) and alkaline desilication (using sodium hydroxide, NaOH, aqueous solutions) treatments. Specifically, the ultrasound-assisted alkaline treatment (i.e., ultrasonic treatment) was proposed as the alternative to conventional alkaline treatments which are performed under hydrothermal conditions. In comparison with the hydrothermal alkaline treatment, the ultrasonic treatment showed the comparatively enhanced efficiency (with the reduced treatment time, i.e., 5 min vs. 30 min, all with 0.2 mol·L NaOH at 65°C) in treating the dealuminated Y zeolites for creating mesoporosity. For example, after the treatment of a dealuminated zeolite Y (using 0.1 mol·L H EDTA at 100°C for 6 h), the ultrasonic treatment produced the mesoporous zeolite Y with the specific external surface area ( ) of 160 m ·g and mesopore volume ( ) of 0.22 cm ·g , being slightly higher than that by the conventional method (i.e., = 128 m ·g and = 0.19 cm ·g ). The acidic property and catalytic activity (in catalytic cracking of -octane) of mesoporous Y zeolites obtained by the two methods were comparable. The ultrasonic desilication treatment was found to be generic, also being effective to treat the dealuminated Y zeolites by citric acid. Additionally, the first step of chemical dealumination treatment was crucial to enable the effective creation of mesopores in the parent Y zeolite (with a silicon-to-aluminium ratio, Si/Al= 2.6) regardless of the subsequent alkaline desilication treatment (i.e., ultrasonic or hydrothermal). Therefore, appropriate selection of the condition of the chemical dealumination treatment based on the property of parent zeolites, such as Si/Al ratio and crystallinity, is important for making mesoporous zeolites effectively.

关键词： zeolite Y     mesoporous zeolite     post-synthesis treatment     ultrasound     chemical dealumination treatment     alkaline desilication treatment    

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Ultrasound-mediated targeted microbubbles: a new vehicle for cancer therapy

Junxiao YE, Huining HE, Junbo GONG, Weibing DONG, Yongzhuo HUANG, Jianxin WANG, Guanyi CHEN, Victor C YANG

《化学科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 20-28 doi: 10.1007/s11705-013-1311-z

摘要： With the hope of overcoming the serious side effects, great endeavor has been made in tumor-targeted chemotherapy, and various drug delivery modalities and drug carriers have been made to decrease systemic toxicity caused by chemotherapeutic agents. Scientists from home and abroad focus on the research of targeted microbubbles contrast agent, and the use of the targeted ultrasound microbubble contrast agent can carry gene drugs and so on to the target tissue, as well as mediated tumor cell apoptosis and tumor microvascular thrombosis block, etc., thus plays the role of targeted therapy. Recent studies have elucidated the mechanisms of drug release and absorption, however, much work remains to be done in order to develop a successful and optimal system. In this review, we summarized the continuing efforts in understanding the usage of the ultrasound triggered target microbubbles in cancer therapy, from release mechanism to preparation methods. The latest applications of ultrasound-triggered targeted microbubbles in cancer therapy, especially in gene therapy and antiangiogenic cancer therapy were discussed. Moreover, we concluded that as a new technology, ultrasound–triggered targeted microbubbles used as drug carriers and imaging agents are still energetic and are very likely to be translated into clinic in the near future.

关键词： ultrasound-mediated     targeted microbubbles     cancer    

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Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound

Chaoran Dou, Qin Li, Tao Ying, Yulin Yan, Xia Wang, Bing Hu

《医学前沿（英文）》 2018年 第12卷 第5期   页码 572-579 doi: 10.1007/s11684-017-0561-4

摘要：

The dimension of the levator hiatus is a possible predictor of pelvic organ prolapse (POP). This retrospective study investigated 360 women who went to urogynecological clinic for pelvic floor discomfort. Levator hiatus dimensions were obtained by three-dimensional transperineal ultrasound and results were compared between women with and without significantly objective prolapse (International Continence Society POP quantification, grade 2 or higher). Receiver operating characteristic (ROC) curve analyses were performed to determine valid screening index for detecting abnormal levator hiatus distensibility. Women with significantly objective prolapse had significantly higher levator hiatus dimensions than those without (all P <0.001). ROC curve analyses confirmed that hiatal area (HA) of 19.5 cm2 during Valsalva maneuver can be used as single-screening index for abnormal levator hiatus distensibility with sensitivity of 0.80 and specificity of 0.70. In this study, we used a two-step method and achieved higher sensibility (0.80 vs. 0.87) without reducing specificity (0.70 vs. 0.71) compared with a single-screening index method. As a result, we suggest that HA≥19.5 cm2 during Valsalva maneuver is an indicator of abnormal levator hiatus distensibility in Chinese women and that the two-step method has higher sensitivity in detecting abnormal distensibility.

关键词： three-dimensional transperineal ultrasound     levator hiatus     levator ani muscle     pelvic organ prolapse    

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标题 作者 时间 类型 操作

High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience

Lian ZHANG, Zhi-Biao WANG

期刊论文

基于超声引导的高精度机器人辅助HIFU 乳腺癌治疗系统

Tianhan Tang,Takashi Azuma,Toshihide Iwahashi,Hideki Takeuchi,Etsuko Kobayashi,Ichiro Sakuma

期刊论文

Ultrasound-guided prostate percutaneous intervention robot system and calibration by informative particle

期刊论文

Anefficient quadrature demodulator for medical ultrasound imaging

Hao ZHOU,Yin-fei ZHENG

期刊论文

高能聚焦超声热治疗恶性肿瘤的初步探索——附78例治疗临床应用报告

何申戌,熊六林,于晋生,兰江

期刊论文

肿瘤光学分子影像前沿技术：追求更精准和更灵敏

王坤,迟崇巍,胡振华,刘沐寒,惠辉,尚文婷,彭冬,张爽,叶津佐,刘海哮,田捷

期刊论文

Time reversal method for guided wave inspection in pipes

DENG Fei, WU Bin, HE Cunfu

期刊论文

Synthesis and characterization of phosphotungstic acid/activated carbon as a novel ultrasound oxidative

Liyan LIU, Yu ZHANG, Wei TAN

期刊论文

Studies of ultrasound disintegration of residual sludge and its energy consumption in water treatment

SHEN Jinfeng, YIN Xuan, GU Heping, Lv Xiaoping

期刊论文

图引导正则最小化的随机超梯度的交替方向方法

Qiang LAN, Lin-bo QIAO, Yi-jie WANG

期刊论文

Entity and relation extraction with rule-guided dictionary as domain knowledge

期刊论文

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

null

期刊论文

Using ultrasound to improve the sequential post-synthesis modification method for making mesoporous Y

Rongxin Zhang, Peinan Zhong, Hamidreza Arandiyan, Yanan Guan, Jinmin Liu, Na Wang, Yilai Jiao, Xiaolei Fan

期刊论文

Ultrasound-mediated targeted microbubbles: a new vehicle for cancer therapy

Junxiao YE, Huining HE, Junbo GONG, Weibing DONG, Yongzhuo HUANG, Jianxin WANG, Guanyi CHEN, Victor C YANG

期刊论文

Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound

Chaoran Dou, Qin Li, Tao Ying, Yulin Yan, Xia Wang, Bing Hu

期刊论文